TRPM7 and colonic neoplasm: Besides TRPM7 and 8, also other Ca2+-influx channels within the TRP-family and other Ca2+-channel protein families have been associated with progression of various types of cancers through EMT and chelation of free cytosolic Ca2+ suppresses the expression of several mesenchymal markers in breast, hepatic and colon cancer cells (reviewed in Iamshanova et al.44).