Further manual curation using PubMed searches identified 11 additional genes involved in vasculogenesis and/or angiogenesis, including, for example, LAMA4 (increased expression in tumor vessels in renal and colon cancer16), LGALS1 (sprouting angiogenesis17), and F2R (PAR1) and MMP1 (MMP1/PAR1 pro-angiogenic signaling18)—total 72.5% (29/40) of genes (Fig. 3, Supplementary Table S6). The gene discussed is F2R; the disease is neoplasm.