TP53 and neoplasm: We selected the genes containing variants based on 3 criteria: (1) genes with the highest MAFs in the tumors, (2) TP53 gene variants and (3) genes in which the MAFs “changed” from pre to post-NAC (either from 0 pre-NAC to a high value post-NAC or, the opposite, from a high value pre-NAC to 0 post-NAC) in the tumor (Supplementary Table S3).