AFP and hepatocellular carcinoma: The ROC curves in Supplementary Fig. 10 also demonstrated that HCC EV Z Score outperformed serum AFP testing in distinguishing early-stage HCC (defined by Milan52 and UNOS DS53 criteria) from at-risk liver cirrhosis with AUC of 0.91 versus 0.68, and 0.92 versus 0.70, respectively.