We recently reported that, in Lepob/ob mice and other rodent models of T2D, sustained diabetes remission can be achieved by a single intracerebroventricular (icv) injection of fibroblast growth factor 1 (FGF1)4, and the hypothalamus has been identified as the brain area responsible for this FGF1 effect5. The gene discussed is FGF1; the disease is type 2 diabetes mellitus.