In addition to projections to other hypothalamic and brainstem nuclei, and to cortical and subcortical structures associated with medial prefrontal cortical network, the extensive distribution of axonal projections from orexin neurons to the central nucleus of the amygdala and the bed nucleus of the stria terminalis putatively supports the synchronization and amplification of their firing activity in anxiety, fear, and motivated states3. This evidence concerns the gene HCRT and Anxiety.