Based on all the findings, we concluded that LINC01559, transmitted via exosomes from MSCs to GC cells, could sequester miR-1343-3p to augment PGK1 and recruit EZH2 to epigenetically repress PTEN, ultimately leading to activated PI3K/AKT pathway to aggravate GC cell proliferation, migration and stemness (Fig. 8). This evidence concerns the gene PTEN and gastric cancer.