We assessed markers of stem cells in the Control, MYCWT, or MYCT58A expressing hyperplastic epidermis following DMBA/TPA treatment and found that MYCT58A expression drives increased expression of Lin28B, CD34, Lgr6, and Sox2. Many reports have shown that CD34 is a stem cell marker in SCC, regulating tumor initiation and progression49,63,64, and a recent study demonstrated that LGR6 is a stem cell marker in skin SCC46. Here, LIN28B is linked to neoplasm.