On the other hand, with the implementation of “targeted” molecular therapies against epidermal growth factor receptor (EGFR) and vascular endothelial growth factor (VEGF), the median overall survival (OS) of patients with metastatic colorectal cancer (CRC) has progressively improved, surpassing 30 months [6–8]. The gene discussed is EGFR; the disease is colorectal carcinoma.