HIF1A and metastatic neoplasm: Univariate analysis of DFS revealed that differentiation type (undifferentiated type, p = 0.0466) and lymph node metastases (positive, p = 0.0146) in primary tumors and grade (B.C, p = 0.0119) and HIF-1α expression (positive, p = 0.0073) in metastatic tumors were significant recurrent factors (Table 4).