hiOL express all major myelin-associated proteins, such as CNP, PLP, MBP, MAG, MOG etc., confirming the oligodendroglial identity, but also some of the proteins which have been found to be unique or enriched on the transcriptional level in oligodendroglial subclusters identified in MS and control brains, such as PDGFRα, BCAN, SOX6, APOE and CD74 [23]. This evidence concerns the gene APOE and myeloid sarcoma.