Expression of PC1/3 and production of GLP-1 in pancreatic alpha cells has been observed after treatment with IL-6 [59], during regeneration of beta cell mass after streptozotocin treatment in neonatal rats [60], during the development of a type 2 diabetes-like phenotype in the gerbil Psammomys obesus [61] or pregnancy in mice [62]. This evidence concerns the gene GLP1R and type 2 diabetes mellitus.