If LSNts sufficiency is confirmed, neural plasticity and/or genetic alterations within this circuit (e.g. by mutations in the Nts gene as observed in Lutter et al., 2017 or changes in ‘allostatic load’; McEwen and Akil, 2020) could contribute to persistent maladaptive eating strategies, such as those observed in eating disorders or in other cases obesity. This evidence concerns the gene NTS and obesity disorder.