CD8A and B-cell chronic lymphocytic leukemia: To optimise the dimensionality reduction and visualise the extent to which discrete subsets of cells are separated from each other in the 31-dimensional space, we performed a linear discriminant analysis (LDA) on four subsets of cells: the predominant CLL cell subpopulation (cluster 9) and CD8 killer cell subpopulation (cluster 2) identified in the study from batches 1 and batch 2.