The targeting end constitutes a soluble T cell receptor (TCR) that recognized the melanocyte-associated antigen glycoprotein 100 (gp100) presented in the context of HLA-A2, which is expressed in approximately 50% of patients with uveal melanoma, and the effector end includes an anti-CD3 single chain variable fragment (scFv). This evidence concerns the gene PMEL and uveal melanoma.