Maternal early-pregnancy glucose and insulin concentrations were not associated with any of the other previously reported maternal gestational diabetes, hyperglycemia or hyperinsulinemia, or adult type 2 diabetes-associated CpGs or differently methylated regions [1, 14, 17, 18, 22, 23, 25, 28–39, 41, 42]. Here, INS is linked to type 2 diabetes mellitus.