The level of canine serum C-reactive protein (CRP), an acute-phase protein released during tissue damage and inflammation, is elevated 100- to 1000-fold in surgical trauma, irritation, and inflammatory diseases, including pyometra, panniculitis, acute pancreatitis, polyarthritis, septic arthritis, and hemangiosarcoma [1–3]. The gene discussed is CRP; the disease is angiosarcoma.