INSR and type 2 diabetes mellitus: SNP rs488672 within host gene TRIM29 was ranked as second most important by BVSe and among the top 30 SNPs by Cox PH and icensmis. RNA sequence data from an animal study involving a mouse model of type 2 diabetes showed that TRIM29 acts as an E3 ligase that targets both insulin receptor (IR) and insulin receptor substrate 1 (IRS1) for ubiquitin-dependent degradation, resulting in insulin resistance [39].