ACKR3 and coronary artery disorder: The result of this study were as follows: (1) the migration, adhesion and tube formation activities of CAD-derived EPCs in vitro, remarkably decreased compared to those of the healthy subjects; (2) diminishing the CXCR7/ERK signaling pathways impaired the CAD-derived EPCs function in vitro; and (3) exposure to shear stress mitigated the impaired EPCs function in the CAD patients by augmenting the CXCR7/ERK pathways.