Analysis of a 1.3 Mb region of homozygosity on CANFA33, which was present in the GWAS PRA cases and absent in the controls, identified a LINE-1 insertion located within the predicted promoter region of IMPG2. PRA in the LA has not been reported in the literature; however, the disease is well recognised anecdotally in the breed and is listed on Schedule A of the UK BVA/KC/ISDS eye scheme. The gene discussed is S100A6; the disease is keratoconus.