With regard to the metrics in tumors with pCR, the percentages of PD1+, CD8+, and PD1+CD8+ T cells, as well as the PD1+CD8+/CD8+ ratio, decreased in the whole tumor (P = 0.028, P = 0.173, P = 0.075, and P = 0.028, respectively) and in the stromal area (P = 0.028, P = 0.249, P = 0.028, and P = 0.028, respectively) (Fig 3b). The gene discussed is CD8A; the disease is neoplasm.