Our data demonstrated that UGDH overexpressing TOV21GHI cells express higher levels of phosphorylated‐ERK, MMP‐2, SIP‐1 and SNAIL, whereas knockdown of UGDH leads to decreases in these markers, indicating that UGDH is involved in regulating ERK, MMP‐2 and EMT markers in ovarian cancer. The gene discussed is MMP2; the disease is ovarian carcinoma.