CRP and Obesity: In a large cohort of 674, Paepegaey et al. [31] showed that CRP increased significantly with BMI (studying five different categories of BMI ranging from 35–40 to 47.4 kg/m2), suggesting that expanded and inflamed AT is the main source of increased circulating CRP in populations with obesity, through the production of cytokines, which stimulate CRP release from the liver.