In a large cohort of 674, Paepegaey et al. [31] showed that CRP increased significantly with BMI (studying five different categories of BMI ranging from 35–40 to 47.4 kg/m2), suggesting that expanded and inflamed AT is the main source of increased circulating CRP in populations with obesity, through the production of cytokines, which stimulate CRP release from the liver. The gene discussed is CRP; the disease is obesity due to melanocortin 4 receptor deficiency.