According to the integrated analyses of 14 eligible case–control studies, our study revealed that the LIPG 584C/T polymorphism was significantly associated with a decreased risk of CAD, which suggested that the LIPG 584C/T polymorphism plays a protective role in the incidence of CAD in individuals and that the T allele may be a protective factor against CAD. This evidence concerns the gene LIPG and coronary artery disorder.