Even though we are able to exclude a role for the IFN pathway in primary pathology, components of this pathway are nevertheless the top elevated pathway in the nGD brain and are also elevated in a number of other LSDs, including mucolipidosis type IV and Krabbe disease [32, 33], along with a number of other unrelated neuroinflammatory disorders [34]. The gene discussed is IFNA1; the disease is mucolipidosis type IV.