The mechanism of action of the Gint4.T aptamer as both high specific targeting agent of human PDGFRβ expressed on the surface of tumor cells and inhibitor of receptor activation and downstream dependent ERK1/2 and PI3K/Akt signaling pathways in GBM [35, 36, 42] and TNBC [31], has been previously clarified and reported in literature and here confirmed for the first time in murine cells. The gene discussed is MAPK3; the disease is glioblastoma.