PDGFRB and cancer: Next, given the driving role of PDGFRβ on cell motility and the ability of Gint4.T to hamper migration and invasion of human cancer cells [22, 31, 35], to confirm its effect on murine receptor upon binding, we proved that the aptamer strongly reduces the PDGF-BB-stimulated migration of 4 T1 and NIH3T3 cells, reaching about 45 and 70% inhibition, respectively, compared to the Scr aptamer (Fig. 2c).