Two genes were upregulated in CHF: AMP deaminase 3 (AMPD3) (log2‐fold change=1.62, false discovery rate=0.0023) and pyridine nucleotide‐disulphide oxidoreductase domain 2 (PYROXD2) (log2‐fold change=1.33, false discovery rate=0.0077), while lactate dehydrogenase C (log2‐fold change=−5.52, false discovery rate=0.0002) was downregulated (Figure 3C). The gene discussed is PYROXD2; the disease is congestive heart failure.