Reviewing TUBB1 and its genetic variations in macrothrombocytopenia to date, we found that reported mutations in mammals included 2 missense mutations, p.R318W and p.F260S in exon 4 in humans [8,16], and a missense mutation of p.D249N in canines [17]. Here, TUBB1 is linked to Macrothrombocytopenia.