Taken together, these results indicate that BACH2 and FUS interaction enhanced the inhibition of the protein levels of WWC3 and YAP phosphorylation, TSLNC8 promoted the protein levels of WWC3 and YAP phosphorylation via miR‐10b‐5p and affected the malignant biological behaviour of glioma cells. Here, WWC3 is linked to central nervous system cancer.