Compared with the LPS group, overexpression of miR-30c-5p markedly inhibited the expression of pyroptosis markers, including TXNIP, NLRP3, caspase-1, and ASC in the renal tissues, suggesting that miR-30c-5p suppressed cell pyroptosis in the kidney during AKI development (Fig. 5 c and d). This evidence concerns the gene CASP1 and acute kidney injury.