In vitro experiments using high sugar, high salt stimulate HUVEC injury model, selection of estrogen receptors antagonist (ICI182780), verify whether acacetin can activate the expression of estrogen receptors, reduce the release of inflammatory factors, improve vasodilatation function, alleviate the endothelial dysfunction, thus improving insulin resistance SHR rats aorta fibrosis. This evidence concerns the gene ESR1 and endothelial dysfunction.