Morphologically similar lesions, such as adenoid cystic carcinoma or salivary basal cell adenocarcinoma, may arise in the oral cavity and oropharynx [45, 46], necessitating awareness of oropharyngeal SCC variants, including those with cylindroma-like features and CYLD mutation. This evidence concerns the gene CYLD and adnexal spiradenoma/cylindroma of a sweat gland.