To determine whether miR-382–3p played a role in lncRNA PSMB8-AS1 mediated oncogenic role of PC cells, PANC-1 and Mia-paca2 cells were co-transfected with lncRNA PSMB8-AS1 shRNA and miR-382–3p inhibitor. The gene discussed is PSMB8; the disease is pachyonychia congenita.