CCK8 and plate clones assays were used to examine the growth of PSMB8-AS1 overexpressed PC cells and co-transfected with sh-STAT1, the results demonstrated that the growth was increased in the PSMB8-AS1 group, and was partially reversed in the PSMB8-AS1 overexpressed and co-transfected with sh-STAT1 (Fig. 6b,c). The gene discussed is STAT1; the disease is pachyonychia congenita.