In this study, we found that PSMB8-AS1 and STAT1 are existing binding sites of miR-382–3p, and demonstrated that PSMB8-AS1 promotes the expression of STAT1/PD-L1, forming a new theoretical basis for pancreatic cancer progression and providing a possible approach for targeted therapy. This evidence concerns the gene PSMB8 and familial pancreatic carcinoma.