Furthermore, chemokine receptor-targeted immunotherapy for thyroid cancer was also worthy of attention, since previous studies have found that chemokines and their receptors such as CXCR1, CXCR2, CXCR3, CXCR4, CXCR7, DARC, CCR3, CCR6, CCR7, and CXCL5-CXCR2 axis play an important role in determining the cellular immunophenotype of thyroid tumor microenvironment [59]. This evidence concerns the gene CXCR4 and thyroid cancer.