Hyperarousal is also considered a key pathophysiological mechanism in insomnia [1], increasing the whole-body metabolic rate during sleep, high-frequency electroencephalographic activity during non-rapid eye movement sleep, and cortisol and adrenocorticotropic hormone levels during the early sleep period, and decreasing parasympathetic tone and HR variability [30, 31]. The gene discussed is POMC; the disease is insomnia.