Hence, we may be unable to detect disease-relevant genetic interactions of DYT genes that are likely to generate dystonia through a fundamental role during brain development, such as TOR1A, THAP1 and KMT2B (Vasudevan et al., 2006; Zhao et al., 2013; Faundes et al., 2018). The gene discussed is THAP1; the disease is Dystonia.