Several biologically coherent associations stand out, including the missense variant rs78534766 in ADCY7, associated with autoimmune conditions (hypothyroidism, inflammatory bowel disease (Luo et al., 2017)) and eosinophil traits; several variants near PIEZO1 associated with varicose veins (Fotiou et al., 2015; Van Hout et al., 2019) and erythroid traits; and a variant (rs45611741) in the 5′ UTR of APOA5 associated with hypercholesterolemia (Nielsen et al., 2019) and Mean Corpuscular Volume (MCV), as well as Mean Corpuscular Hemoglobin Concentration (MCHC). The gene discussed is ADCY7; the disease is hypothyroidism.