APOA5 and Hypercholesterolemia: Several biologically coherent associations stand out, including the missense variant rs78534766 in ADCY7, associated with autoimmune conditions (hypothyroidism, inflammatory bowel disease (Luo et al., 2017)) and eosinophil traits; several variants near PIEZO1 associated with varicose veins (Fotiou et al., 2015; Van Hout et al., 2019) and erythroid traits; and a variant (rs45611741) in the 5′ UTR of APOA5 associated with hypercholesterolemia (Nielsen et al., 2019) and Mean Corpuscular Volume (MCV), as well as Mean Corpuscular Hemoglobin Concentration (MCHC).