Moreover, treatment of prostate cancer cells with tubacin, an HDAC6 inhibitor, in a dose-dependent manner completely inhibited TGF-β-induced expression of c-Jun mRNA, as well as migration and invasion (Figures 8, S1C, S1D, S1G, and S1H), giving further experimental evidence for the important role for HDAC6 in TGF-β-induced migration and invasiveness of cancer cells and support for the potential usefulness of HDAC6 inhibitors for patients with aggressive prostate cancer. This evidence concerns the gene HDAC6 and Familial prostate cancer.