Meanwhile, other researcher found that in oesophageal cancer cells, depletion of SLC52A3 would increase p21 and p27 protein levels, decreased cyclin E1 and Cdk2 leading to cell cycle arrest at G1‐G1/S,8 suggested that SLC52A3 rs13042395 C > T change played a complicated role in oesophageal squamous cell carcinoma. The gene discussed is SLC52A3; the disease is carcinoma of esophagus.