In the second subgroup of 42 patients, 3 (7%) carried a pathogenic variant (T13240G, G12299A, 14058delG) in TP53. The recommendation from this report was that women with early-onset BC who had a family history consistent with LFS have a high probability of carrying a germline TP53 pathogenic variant and that subgroups of families with early-onset BC might warrant TP53 screening irrespective of meeting the Chompret and LFS criteria [14]. Here, TP53 is linked to breast cancer.