Interestingly, our lead 1q32 variant (rs1398148) maps to PIK3C2B and is in LD (r2 > 0.60) with known MDM4 cancer risk variants7,8, suggesting that the 1q32 locus may be involved in modulating both p53-and PI3K-mediated oncogenic pathways. The gene discussed is MDM4; the disease is cancer.