Genome-wide association studies (GWAS) of individual cancers have identified loci associated with multiple cancer types, including 1q32 (MDM4)7,8; 2q33 (CASP8-ALS2CR12)9,10; 3q28 (TP63)11,12; 4q24 (TET2)13,14; 5p15 (TERT-CLPTM1L)9,12; 6p21 (HLA complex)15,16; 7p1517; 8q2412,18; 11q1318,19; 17q12 (HNF1B)18,20; and 19q13 (MERIT40)21. This evidence concerns the gene CASP8 and cancer.