It is also important to note that, despite the lack of significant overrepresentation, other neurovascular or neurodegenerative disease-associated genes with differential expression in the aged brain endothelium may still carry functional implications that are yet to be revealed (e.g. Nbeal1, associated with cerebral small vessel disease/stroke and most upregulated in aged arterial ECs, see Fig. 3a and Supplementary Table 3). The gene discussed is NBEAL1; the disease is cerebral small vessel disease.