We further assessed pleiotropy of the SCAD-associated loci in the UKB published results (http://geneatlas.roslin.ed.ac.uk/phewas/; PheWAS32), demonstrating associations of chr6p24.1 rs9349379-G (PHACTR1) and chr21q22.11 rs28451064-A (MRP6/KCNE2) with CAD (Supplementary Data 5). This evidence concerns the gene PHACTR1 and spontaneous coronary artery dissection.