PHACTR1 and Headache: The chromosome 6p24.1 PHACTR1 locus rs9349379-A allele has been associated with SCAD, FMD, cervical artery dissection, migraine headache, and hypertension, and the rs9349379-G allele has been associated with coronary artery disease (CAD) and MI more typically due to atherothrombotic mechanisms and more frequently occurring in men13,16,17,28,29.