The chromosome 6p24.1 PHACTR1 locus rs9349379-A allele has been associated with SCAD, FMD, cervical artery dissection, migraine headache, and hypertension, and the rs9349379-G allele has been associated with coronary artery disease (CAD) and MI more typically due to atherothrombotic mechanisms and more frequently occurring in men13,16,17,28,29. This evidence concerns the gene PHACTR1 and spontaneous coronary artery dissection.