Meta-analysis of the genome-wide SCAD discovery and replication results identified additional genome-wide significant associations at the chromosome 12q13 LRP1 locus (rs11172113) and the chromosome 6p24.1 PHACTR1 locus (rs9349379) (Table 1, Supplementary Data 1, Fig. 2, Supplementary Data 2). Here, LRP1 is linked to spontaneous coronary artery dissection.