Furthermore, we compared the GRS model with a model restricted to known SNPs previously shown to be associated with JIA.15 Using this restricted model, we achieved AUC of 0.614, 0.642 and 0.648 for the UK, CHOP and CLARITY, respectively, showing that the unrestricted GRS model was a stronger risk predictor. The gene discussed is DDIT3; the disease is juvenile idiopathic arthritis.