ESR1 and breast carcinoma: However, the associations observed in the overall data were present among women ≥ 50 years old [HRs 0.89 (0.77, 1.03), 0.96 (0.80, 1.15), and 0.76 (0.57, 1.01), for overall, ER+, and ER− breast cancer, respectively], while there were no apparent associations for women < 50 years of age.