ANG and viral infectious disease: The final longer tRF type, 30–50 bases in length, are called tRNA-derived stress-induced RNAs (tiRNAs) or tRNA halves and are generated by specific cleavage in the anticodon loops of mature tRNAs by angiogenin (ANG) under stress conditions, such as hypoxia, starvation, virus infection, arsenite, heat shock, or heavy metal-induced cellular stress/toxicity [15, 26–30].