JAG2 and colorectal carcinoma: Relating to the metastasis of colorectal cancer (CRC), one study demonstrated that tRF/miR-1280, derived from both tRNA-Leu and pre-miRNA, suppresses Notch/Gata and miR-200b signaling through a direct interaction with the 3′-UTR of Notch ligand JAG2 and plays important roles in CRC growth and metastasis [73].