Then, a T-cell- inflamed TME is elicited: increased tumor-infiltrating neutrophils (CD11b+Ly6c+Ly6g+), the polarization from M2 macrophages to M1 macrophages (decreased CD206), overexpression of CD86 in tumor-drainaged lymph nodes, increased CD8+ and CD4+ T cells and increased CD8+/CD4+ T-cell ratio [126]. The gene discussed is CD4; the disease is neoplasm.