CRP and infection: As contradictory results exist regarding whether changes in serum markers can guide the timing of reimplantation in two-stage exchange arthroplasty after total joint arthroplasty (TJA), we investigated (1) whether percent or delta changes in serum indicators, which included the erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), interleukin-6 (IL-6), and fibrinogen are useful for predicting infection eradication; and (2) whether value changes in these four serum markers can guide the proper timing of reimplantation.