The five scFvs (FTD-TDP1, FTD-TDP2, FTD-TDP3, FTD-TDP4 and FTD-TDP5) were used to assay sera samples from FTD-TDP (n = 12), FTD-tau (n = 12), AD sera (n = 11) and controls (n = 10) (Fig. 3). This evidence concerns the gene TDP2 and Alzheimer disease.