HMOX1 and metabolic dysfunction-associated steatohepatitis: Moreover, another study demonstrated that a phenolic fraction of Lonicera caerulea L. ameliorated inflammation and lipid peroxidation by upregulating Nrf2 and SOD and downregulating the transcription factor forkhead box protein O1 and HO-1 in a mouse model of nonalcoholic steatohepatitis (NASH) induced by a high-fat diet in combination with CCl4 [97].