In the present study, we observed the following results: (i) PROK2 is high expressed in cervical cancer and is positively correlated with shorter OS and DFS of cervical cancer patients; (ii) PROK2 knockdown by shPROK2 significantly decreases the capacity of migration and invasion in human cervical cancer cells; (iii) PROK2 knockdown shows no influence on cell growth, the induction of cell cycle arrest or apoptosis; (iv) MMP15 expression is positively regulated by PROK2. Here, MMP15 is linked to cervical carcinoma.